Stadium: Tullio Field Round: 1
| NCAA Division I, FCS, Playoffs | 2019/10/05 16:00 | Mercyhurst Lakers v Slippery Rock | L | 14-45 |
| NCAA Division I, FCS, Playoffs | 2018/09/29 22:00 | Slippery Rock v Mercyhurst Lakers | L | 41-21 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 16:00 | Edinboro Fighting Scots v Mercyhurst Lakers | W | 20-27 |
| NCAA Division I, FCS, Playoffs | 2021/10/09 16:00 | Mercyhurst Lakers v Seton Hill Griffins | L | 17-19 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 19:00 | California Vulcans v Mercyhurst Lakers | L | 37-0 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 17:00 | Mercyhurst Lakers v Iup Crimson Hawks | L | 13-48 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst Lakers | L | 17-7 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 16:00 | Mercyhurst Lakers v West Chester Golden Rams | L | 10-56 |
| NCAA Division I, FCS, Playoffs | 2021/09/04 22:00 | Mercyhurst Lakers v Alderson Broaddus Battlers | W | 18-3 |
| NCAA Division I, FCS, Playoffs | 2019/11/16 17:00 | Millersville University of Pennsylvania Marauders v Mercyhurst Lakers | W | 7-17 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 17:00 | Slippery Rock v Iup Crimson Hawks | L | 21-48 |
| NCAA Division I, FCS, Playoffs | 2021/10/09 18:00 | Edinboro Fighting Scots v Slippery Rock | W | 13-49 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 22:00 | Slippery Rock v Clarion University Golden Eagles | W | 75-0 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 22:00 | Seton Hill Griffins v Slippery Rock | W | 17-41 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 22:00 | Lock Haven U. BE v Slippery Rock | W | 7-57 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 22:00 | Slippery Rock v East Stroudsburg Warriors | W | 22-7 |
| NCAA Division I, FCS, Playoffs | 2021/09/02 22:00 | Wayne State Warriors v Slippery Rock | W | 21-24 |
| NCAA Division I, FCS, Playoffs | 2019/12/14 17:30 | Slippery Rock v Minnesota State Mankato Mavericks | L | 15-58 |