Stadium: Tullio Field Round: 1
| NCAA Division I, FCS, Playoffs | 2019/11/02 16:00 | Mercyhurst Lakers v Gannon University Golden Knights | W | 28-7 |
| NCAA Division I, FCS, Playoffs | 2018/10/27 16:00 | Gannon University Golden Knights v Mercyhurst Lakers | W | 21-38 |
| NCAA Division I, FCS, Playoffs | 2021/10/30 16:00 | Clarion University Golden Eagles v Mercyhurst Lakers | W | 20-38 |
| NCAA Division I, FCS, Playoffs | 2021/10/23 16:00 | Mercyhurst Lakers v Slippery Rock | L | 17-20 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 16:00 | Edinboro Fighting Scots v Mercyhurst Lakers | W | 20-27 |
| NCAA Division I, FCS, Playoffs | 2021/10/09 16:00 | Mercyhurst Lakers v Seton Hill Griffins | L | 17-19 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 19:00 | California Vulcans v Mercyhurst Lakers | L | 37-0 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 17:00 | Mercyhurst Lakers v Iup Crimson Hawks | L | 13-48 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst Lakers | L | 17-7 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 16:00 | Mercyhurst Lakers v West Chester Golden Rams | L | 10-56 |
| NCAA Division I, FCS, Playoffs | 2021/10/30 16:00 | Gannon University Golden Knights v Slippery Rock | L | 21-63 |
| NCAA Division I, FCS, Playoffs | 2021/10/23 16:00 | Gannon University Golden Knights v Edinboro Fighting Scots | W | 21-18 |
| NCAA Division I, FCS, Playoffs | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | W | 10-14 |
| NCAA Division I, FCS, Playoffs | 2021/10/09 16:00 | Gannon University Golden Knights v California Vulcans | L | 17-38 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 18:00 | Iup Crimson Hawks v Gannon University Golden Knights | L | 28-23 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 17:00 | Gannon University Golden Knights v Clarion University Golden Eagles | W | 56-21 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 18:00 | Bloomsburg Huskies v Gannon University Golden Knights | L | 31-27 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 16:00 | Gannon University Golden Knights v Shepherd Rams | L | 26-56 |