| Colombia Primera C | 2021/08/10 17:00 | Real Santuario v Antioquia FC | L | 1-3 |
| Primera B, Apertura, Promotion, Group A | 2021/07/18 19:21 | CD Gallegol v Real Santuario | L | 3-2 |
| Primera B, Apertura, Promotion, Group A | 2021/07/04 17:16 | CD Los Del Sur v Real Santuario | W | 2-4 |
| Primera B, Apertura, Promotion, Group A | 2021/06/26 19:13 | Real Santuario v Club Deportivo La Chalaca | D | 2-2 |
| Primera B, Apertura, Promotion, Group A | 2021/06/20 18:00 | 리오네그로 아귈라스 v Real Santuario | L | 4-2 |
| Primera B, Apertura, Promotion, Group A | 2021/06/06 15:00 | Sellos Colombianos v Real Santuario | W | 0-1 |
| Primera B, Apertura, Promotion, Group A | 2021/07/16 17:17 | Club Deportivo La Chalaca v Deportivo Alexis Garcia | W | 1-2 |
| Primera B, Apertura, Promotion, Group A | 2021/07/04 13:00 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | L | 1-0 |
| Primera B, Apertura, Promotion, Group A | 2021/06/19 17:38 | Total Soccer FC v Deportivo Alexis Garcia | L | 2-1 |
| Primera B, Apertura, Promotion, Group A | 2021/06/13 17:00 | Deportivo Alexis Garcia v Molino Viejo | L | 0-2 |
| Primera B, Apertura, Promotion, Group A | 2021/03/19 16:15 | Talento y Vida v Deportivo Alexis Garcia | W | 1-2 |
| Primera B, Apertura, Promotion, Group A | 2021/02/10 15:00 | Estudiantes de Medellin v Deportivo Alexis Garcia | L | 2-0 |
| Primera B, Apertura, Promotion, Group A | 2021/01/31 21:00 | Deportivo Alexis Garcia v Ferrovalvulas FC | D | 0-0 |