Stadium: Bailey Memorial Stadium Round: 1
| NCAA Division I, FCS, Playoffs | 2021/03/13 17:00 | Morehead State v Presbyterian | L | 16-31 |
| NCAA Division I, FCS, Playoffs | 2021/10/02 18:00 | Dayton v Morehead State | W | 38-45 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 19:00 | Morehead State v Austin Peay | L | 35-59 |
| NCAA Division I, FCS, Playoffs | 2021/09/04 22:00 | Morehead State v James Madison | L | 10-68 |
| NCAA Division I, FCS, Playoffs | 2021/04/17 20:00 | Butler Bulldogs v Morehead State | W | 18-28 |
| NCAA Division I, FCS, Playoffs | 2021/04/10 16:00 | Valparaiso Crusaders v Morehead State | W | 24-28 |
| NCAA Division I, FCS, Playoffs | 2021/04/03 19:00 | Morehead State v Butler Bulldogs | W | 35-14 |
| NCAA Division I, FCS, Playoffs | 2021/03/27 16:00 | Morehead State v Davidson Wildcats | L | 21-24 |
| NCAA Division I, FCS, Playoffs | 2021/03/20 16:00 | Stetson Hatters v Morehead State | W | 14-31 |
| NCAA Division I, FCS, Playoffs | 2021/09/25 17:00 | Presbyterian v Dayton | L | 43-63 |
| NCAA Division I, FCS, Playoffs | 2021/09/18 22:00 | Presbyterian v Campbell | L | 0-72 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 20:00 | Presbyterian v Fort Lauderdale Soaring Eagles | W | 68-3 |
| NCAA Division I, FCS, Playoffs | 2021/09/04 20:00 | Presbyterian v St. Andrews Knights | W | 84-43 |
| NCAA Division I, FCS, Playoffs | 2021/04/17 18:00 | Presbyterian v Drake | W | 28-24 |
| NCAA Division I, FCS, Playoffs | 2021/04/10 15:00 | Davidson Wildcats v Presbyterian | W | 24-29 |
| NCAA Division I, FCS, Playoffs | 2021/04/03 17:00 | Presbyterian v Stetson Hatters | W | 26-3 |
| NCAA Division I, FCS, Playoffs | 2021/03/27 15:00 | San Diego v Presbyterian | L | 24-21 |