Stadium: Tullio Field Round: 1
| NCAA Division I, FCS, Playoffs | 2019/09/14 19:00 | Mercyhurst Lakers v Shepherd Rams | L | 17-22 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst Lakers | L | 7-0 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 16:00 | Mercyhurst Lakers v California Vulcans | L | 20-44 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 16:00 | Gannon University Golden Knights v Mercyhurst Lakers | L | 49-14 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 22:00 | Mercyhurst Lakers v Clarion University Golden Eagles | L | 21-23 |
| NCAA Division I, FCS, Playoffs | 2022/10/08 22:00 | Slippery Rock v Mercyhurst Lakers | L | 31-17 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 18:00 | Mercyhurst Lakers v Edinboro Fighting Scots | L | 13-16 |
| NCAA Division I, FCS, Playoffs | 2022/09/24 20:00 | Iup Crimson Hawks v Mercyhurst Lakers | L | 33-16 |
| NCAA Division I, FCS, Playoffs | 2022/09/17 16:00 | Mercyhurst Lakers v Kutztown Golden Bears | L | 31-50 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 17:05 | East Stroudsburg Warriors v Shepherd Rams | W | 14-37 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 16:00 | Shepherd Rams v Bloomsburg Huskies | W | 55-10 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 16:00 | West Chester Golden Rams v Shepherd Rams | W | 14-47 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 16:00 | Shepherd Rams v Millersville University of Pennsylvania Marauders | W | 55-17 |
| NCAA Division I, FCS, Playoffs | 2022/10/08 16:00 | Shepherd Rams v Lock Haven U. BE | W | 72-7 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 17:00 | Shippensburg Raiders v Shepherd Rams | W | 13-30 |
| NCAA Division I, FCS, Playoffs | 2022/09/24 16:00 | Kutztown Golden Bears v Shepherd Rams | W | 35-42 |
| NCAA Division I, FCS, Playoffs | 2022/09/17 16:00 | Shepherd Rams v California Vulcans | W | 26-23 |