| Primera B, Apertura, Promotion, Group A | 2022/03/18 14:10 | Medellin City FC v Politecnico J.I.C. | D | 0-0 |
| Primera B, Apertura, Promotion, Group A | 2022/09/21 15:00 | Molino Viejo v Medellin City FC | L | 3-0 |
| Primera B, Apertura, Promotion, Group A | 2022/09/07 17:00 | Sol de Oriente v Medellin City FC | L | 2-1 |
| Primera B, Apertura, Promotion, Group A | 2022/08/30 15:00 | Medellin City FC v FC Leones Reserves | W | 4-0 |
| Primera B, Apertura, Promotion, Group A | 2022/08/15 15:13 | Real Santuario v Medellin City FC | L | 4-0 |
| Primera B, Apertura, Promotion, Group A | 2022/08/02 19:17 | Medellin City FC v Universidad de Antioquia | L | 0-1 |
| Primera B, Apertura, Promotion, Group A | 2022/07/11 16:00 | CD Gallegol v Medellin City FC | W | 2-4 |
| Primera B, Apertura, Promotion, Group A | 2022/07/05 15:23 | Medellin City FC v E.D.P IND. Medellin | W | 4-1 |
| Primera B, Apertura, Promotion, Group A | 2022/06/16 12:19 | Molino Viejo v Medellin City FC | L | 3-1 |
| Primera B, Apertura, Promotion, Group A | 2022/09/20 17:00 | Total Soccer FC v Politecnico J.I.C. | D | 0-0 |
| Primera B, Apertura, Promotion, Group A | 2022/09/06 17:00 | Politecnico J.I.C. v Club Deportivo La Chalaca | W | 3-1 |
| Primera B, Apertura, Promotion, Group A | 2022/08/30 00:00 | Real San Jeronimo v Politecnico J.I.C. | L | 2-1 |
| Primera B, Apertura, Promotion, Group A | 2022/07/20 21:27 | Estudiantes de Medellin v Politecnico J.I.C. | L | 1-0 |
| Primera B, Apertura, Promotion, Group A | 2022/06/15 17:18 | Sol de Oriente v Politecnico J.I.C. | D | 0-0 |
| Primera B, Apertura, Promotion, Group A | 2022/05/24 17:12 | Real Santuario v Politecnico J.I.C. | L | 3-0 |
| Primera B, Apertura, Promotion, Group A | 2022/05/03 17:09 | Politecnico J.I.C. v Independiente Sabaneta | W | 3-1 |
| Primera B, Apertura, Promotion, Group A | 2022/04/25 16:18 | CD Gallegol v Politecnico J.I.C. | L | 2-1 |