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The Louisville Cardinals baseball team is the varsity intercollegiate baseball program of the University of Louisville, located in Louisville, Kentucky. The program was a member of the NCAA Division I American Athletic Conference for the 2014 season and joined the Atlantic Coast Conference in July 2014. The Cardinals have played at Jim Patterson Stadium since the venue opened during the 2005 season. Dan McDonnell has been the program's head coach since the start of the 2007 season. As of the end of the 2017 season, the program has appeared in 13 NCAA tournaments and five College World Series. In conference postseason play, it has won two Big East Conference baseball tournaments. In regular season play, it has won two Metro Conference titles, four Big East Conference titles, one American Athletic Conference title, and four Atlantic Coast Conference titles. Louisville also set the ACC record for most conference wins in a season with 25 during the 2015 season.

As of July 20, 2019, 19 former Cardinals have appeared in Major League Baseball. Seven former Cardinals have appeared in MLB games during the 2019 season: Nick Burdi, Adam Engel, Chad Green, Matt Koch, Brendan McKay, Josh Rogers, Will Smith, and Nick Solak