| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 06/06 19:00 | - | Santos Laguna v Toluca | L | 2-3 |
| 06/03 01:00 | - | Santos Laguna v Monarcas Morelia | D | 1-1 |
| 05/30 19:00 | - | Guadalajara Chivas v Santos Laguna | L | 3-1 |
| 05/28 00:00 | - | G. Blancos Queretaro v Santos Laguna | W | 2-3 |
| 05/22 19:30 | - | Santos Laguna v San Luis | W | 1-0 |
| 05/19 01:30 | - | Santos Laguna v America | L | 2-4 |
| 05/15 21:00 | - | Rayados de Monterrey v Santos Laguna | L | 3-1 |
| 05/13 19:00 | - | Santos Laguna v Necaxa | L | 2-7 |
| 05/09 19:30 | - | Pachuca v Santos Laguna | L | 1-0 |
| 05/06 01:00 | - | Santos Laguna v Atlas | W | 2-1 |
| 05/01 19:00 | - | Juarez v Santos Laguna | W | 1-3 |
| 04/27 19:30 | - | Santos Laguna v Tigres UANL | L | 0-4 |
| 04/24 22:15 | - | Puebla v Santos Laguna | W | 0-6 |
| 04/23 01:00 | - | Santos Laguna v Universidad Nacional | W | 2-0 |
| 04/18 19:00 | - | Cruz Azul v Santos Laguna | W | 3-4 |
| 04/15 19:00 | - | Santos Laguna v Leon | L | 1-4 |
| 04/13 01:00 | - | Tijuana de Caliente v Santos Laguna | W | 1-5 |